Hormone injection can help weight loss in patients with obesity, a study suggests. The study was randomly published in the popular journal called ‘Diabetes Care’.
Researchers wanted to see if infusing patients with the GOP hormone glucagon-like peptide-1 (GLP-1), oxyntomodulin, and peptide could reduce weight and lower glucose levels to mimic the high levels seen after bariatric surgery.
Fifteen patients were given Hormone injection GOP treatment for four weeks using a slow injection pump of the GOP mixture under the skin for 12 hours per day, starting one hour before breakfast and disconnected after the last meal of the day. Patients took a diet from a dietitian about healthy eating and weight loss.
“Obesity and type 2 diabetes can lead to very serious and life-threatening conditions such as cancer, stroke and heart disease. There is a real need to find new drugs, so we can improve the lives of many patients,” says Tricia Tan, lead author of the study.
Twenty-six obese patients with prediabetes and those with diabetes were recruited for the study from July 2016 to October 2018.
Fifteen patients were randomly selected to receive Hormone injection therapy and 11 patients were given a placebo saline (saline) infusion over a period of four weeks.
The group recruited 21 patients undergoing bariatric surgery and 22 patients who followed a low-calorie diet to compare GOP outcomes.
All patients were given a glucose monitoring device to track their glucose levels after treatment. In the trial, patients undergoing GOP treatment lost an average of 4.4 kg, compared with 2.5 kg for participants receiving a saline placebo. There are also no side effects to treatment.
However, patients who received bariatric surgery or who consumed a very low-calorie diet lost significantly more weight than GOP patients. Changes in weight were 10.3 kg for a bariatric patient and 8.3 kg for patients who followed a very low-calorie diet.
“Although weight loss is small, it is better to use a GOP infusion because it has fewer side effects than bariatric surgery,” says Tan.
“This result shows that it is possible to reap some of the benefits of a gastric bypass operation without having to undergo surgery,” Tan said. The group found that GOP had the ability to lower blood glucose levels to normal levels, with little difference in blood glucose.